Thursday, July 16, 2020

CVA

This is an online E log book to discuss our patient's de-identified health data shared after taking his/her/guardian's signed informed consent. 

Here we discuss our individual patient's problems through series of inputs from available global online community of experts with an aim to solve those patient's clinical problems with collective current best evidence based inputs. 

This E log book also reflects my patient-centered online learning portfolio and your valuable inputs on the comment box is welcome.
 
CASE PRESENTATION:
 
A 60year old female resident of bollaram , farmer by occupation  came to the hospital with the chief complaints of Drooling of saliva with slurring of speech since 7 days . weakness in the left upper and lower limb with deviation of mouth to right side since  6 days.


HOPI: 
 Patient  was apparently asymptomatic  4-5 years back , then she developed tingling and numbness sensation  Associatedw intermittent headache , neck pain, giddiness  for which she had been to a hosiptal  diagnosed with hypertension and was under medication (Tab ATEN 50mg od)
Suddenly she had deviation of mouth to right side with drooling of saliva. Associated with slurring of speech in the morning at 8:,00 am during breakfast   1 week back 
.
Then weakness of left upper limb since 6 days for which she tried lifting objects with left upper limb to regain her strength in that affected limb
Weakness of left lower limb since 4 days. Then after she was taken to nearby hospital where her BP was around 190/110 and CT scan was done showing an acute infarct in the right corona radiata and  treatment was given.
Inability to use her limbs which was sudden in onset  with progressive in nature. 
H/o pain in left hip joint and elbow joint.
No h/o trauma.
No h/o fever, diarrhoea, vomitings, cough, shortness of breath,  chestpain, orthopnea, paroxysmal nocturnal adyspnea, 

No h/o involuntary movements, neck stiffness, wasting or thinning of muscles.

PAST HISTORY:
 K/c/o hypertension since 4-5 years and is on tab. ATEN 50mg.
No h/o diabetes mellitus, epilepsy , bronchial asthma, chronic heart and kidney diseases, tuberculosis, thyroid disorders.
No previous surgeries and blood transfusion.
 
PERSONAL HISTORY: 
Diet: mixed
Appetite: normal
Sleep: adequate
Bowel and bladder movements: regular.
No addictions.

FAMILY HISTORY: 
No significant family history.

DRUG HISTORY: 
Not allergic to any known drugs.

GENERAL EXAMINATION: 
Patient is conscious, coherent and cooperative.
Moderately built and moderately nourished.
No signs of pallor, icterus, cyanosis , clubbing, kilonychia, generalised lymphadenopathy, bilateral pedal edema.
 
VITALS:
Temperature: afebrile
Pulse rate: 80 beats per min
BP: 140/ 100 mm of hg
RR: 22 cycles per min.
Sp02 : 99% at room temperature
GRBS: 127 mg/dl.

SYSTEMIC EXAMINATION:

-CNS:

- Higher mental functions: conscious and alert with slurred speech.

- Spinomotor :   no wasting/ thinning of muscles. No  pain, fatigue and fasciculations.

                              Right.                 Left.

Bulk :.                      Normal.          Normal
Tone: 
      Upper limb:.     Normal.          Decreased
      Lower limb:.     Normal.          Decreased
Power:
      Upper limb:.     4+/5.                2</5
      Lower limb:.     4+/5.                3/5  

-Motor system
Reflexes:  
   Superficial reflexes: normal
   Deep tendon reflexes: 
      Biceps:.             +.                      ++
      Triceps:.            +.                      ++
      Supinator:.         -.                       +
      Knee:.                 -.                       ++
      Ankle:.                -.                        +
      Plantar:.             Withdrawal.    Extensor
 












-Sensory system:     right.   Left
                   Fine touch +.        -
               Vibration.      +.      -
            Position sense +.      -
           Crude touch.      +.      +
       pain and temperature +.  +
-Cranial nerve examination:
     Vll:  Deviation of mouth to right side.
            Drooling of saliva present 
            Able to close eyes.
           frowning present on both sides on forehead 
    Others cranial nerves: normal.

-ANS: Able to feel bladder fullness, regular bladder movements. No sweating and palpitations.

- Meninges: no fever, headache, neck stiffness, nausea and vomitings.

-PERABDOMINAL EXAMINATION:
 
Shape of abdomen: scaphoid
No tenderness and local rise of temperature.
No palpable masses.
Hernial orifices normal.
No free fluid and bruit.
Liver and spleen : not palpable.
Bowel sounds: normally heard.
 
-RESPIRATORY SYSTEM:
Position of trachea: normal
No wheeze and dyspnea.
Bilateral air entry present.
Normal vesicular breath sounds heard.
No adventitious sounds.

-CVS:
S1 and S2 heard.
No murmurs.

-Based on above findings, the following investigations were sent.
Hemogram
Hb:11 gms
RBC: 3.8 million
platelets 1.7 lakhs
WBC:10900
Smear:normocytic normochromic.
polymorpholeukocytosis

CUE:
colour:light yellow
appearance: slightly turbid
reaction:acidic
albumin: trace
sugar: nil
pus cells: 2-3/HPF
Epithelial cells: 1-2 /HPF

Parasite F: negative
 
CT brain report:  Acute infarct in right corona radiata. MCA territory.

MRI REPORT:
Acute infarct in right parietal and temporal lobe:MCA territory
serum creatinine 0.9 mg/ dl
sodium 142 mMol/ lit
potassium 3.9 mMol/lit
chloride 101 mMol /lit
RBS 134  mg/ dl
Blood urea 1.1 mg/ dl
serum uric acid 5.7 mg/ dl

LFT
Total bilirubin 0.9 mg/ dl
Direct bilirubin 0.1 mg/ dl
Indirect bilirubin 0.8 mg/ dl
SGPT 28 U/L
SGOT 34U/L
ALP 88 IU/ L
Total proteins 6.2 gms/ dl
Albumin 3.2 gms/ dl
Globulin 3.0 gms/ dl
A/G ratio 1.0

HIV Negative
HBsAg negative
VDRL negative

PT : 18 Sec
APTT:34 sec
INR : 1.3 Sec
BT: 2 min
CT : 4 min
ESR:57mm.
 
2d ECHO: normal

Carotid Doppler:  Proximal right ICA has a calcified plaque at the bulb, causing approx <20% occlusion with no significant stenosis.
Left ICA has small plaque causing no significant stenosis.

Xray pelvis with both hips: normal.

FLP:  Total cholesterol: 100
         Triglycerides: 83mg/dl
         Hdl cholesterol: 40 mg/dl
         Ldl cholesterol:  59 mg/dl
         Vldl : 16.6 mg/dl

PROVISIONAL DIAGNOSIS: 
 CVA - left side hemiparesis with acute infarct in right temporal and parietal lobe. With left UMN facial palsy involving MCA territory. 
K/c/o hypertension.


MANAGEMENT:
1) Tab. Aspirin 75 mg po/ od
2) Tab. Clopitab 75mg po/ od
3) Tab. Atorvastatin  20mg po h/s
4) Tab. Pregabalin 75mg h/s
5)  Inj. Optineuron 1amp in 500ml NS / IV / od
6)  Tab. Pan 40 mg po/ od
8) physiotherapy of left upper and lower limbs.


      








               





Thursday, July 9, 2020

Status epilepticus

This is an online E log book to discuss our patient's de-identified health data shared after taking his/her/guardian's signed informed consent. 

Here we discuss our individual patient's problems through series of inputs from available global online community of experts with an aim to solve those patient's clinical problems with collective current best evidence based inputs. 

This E log book also reflects my patient-centered online learning portfolio and your valuable inputs on the comment box is welcome.


CASE PRESENTATION:
A 33 year old female,resident of narketpally, housewife by occupation came with the chief complaint of Headache and neck pain since 3 days.
And. involuntary movements of all four limbs since evening 7:00 pm

HOPI:
Patient was apparently asymptomatic 3 days back, then she developed headache, associated with neckpain.  Pain was over occipital region , dragging type, constant throughout the day. Associated with tingling of lower and upper limbs. Also associated with blurring of vision. 
No diurnal variation, vomitings, neck stiffness, fever , diplopia.
-H/o fall at 5 pm,  with black outs, giddiness, with loss of  consciousness chest pain for 10 mins. Regained conscious and tried to walk.
At 8pm, they went to nearby rmp doctor and they were given medication.

-At that point She had an episode of seizures at 9pm with tonic clonic movements of right upper and lower limbs with  frothing from mouth. Loss of consciousness for 10 mins. 
Seizures were preceded by chest pain, palpitations, sweating, visual disturbance, 
No nausea, vomiting, sphincter incontinence, breathing pattern abnormality.
No tongue bite, deviation of mouth, uprolling of eye balls.
Recovered spontaneously  with confusion and residual weakness(?Todds paralysis)
There was an another episode of seizures after 10mins lasting for 10mins with generalized tonic clonic movements of all the 4 limbs. And brought to our hospital with on going seizures.
 Total no of seizures: 7-8 episodes in the hospital stay from 9:00 pm to next day morning 8:00 am each seizure episode lasting for 1-2 minutes with no complete regain of consciouness in between the seizure interval 
Sensorium between episode was drowsy but arousable.
No sustained injuries.
No speech abnormality.
 



PAST HISTORY:
K/c/o epilepsy. She had seizure activity 5 years ago and was under ayurvedic treatment  for 1 year and stopped.
No h/o hypertension, diabetes mellitus, chronic kidney disease, chronic heart disease, bronchial asthma, tuberculosis, thyroid disorders.
No h/o previous surgeries and blood transfusion.

PERSONAL HISTORY: 
Diet: mixed
Appetite: normal
Sleep: adequate
Bowel and bladder movements: regular
No addictions

FAMILY HISTORY:
No similar complaints in the family

DRUG HISTORY:
Not allergic to any known drugs.

MENSTRUAL HISTORY: 
Age of menarche: 12 years.
She bleeds for 4 days for every 30 days. Cycles are regular with no pain and clots.

GENERAL EXAMINATION: 
Patient is in drowsy but arousable.
Patient is moderately built and moderately nourished.
No signs of pallor, icterus, cyanosis, clubbing, kilonychia, generalised lymphadenopathy, bilateral pedal edema.

VITALS:
Temperature: afebrile
Pulse rate: 63 beats per min
Respiratory rate: 36 cycles per min.
Blood pressure: 150/100 mm of hg
Spo2 : 98% at room temperature.
Grbs: 106 mg%.
 
SYSTEMIC EXAMINATION: 

-CNS:
-Higher mental functions:  
drowsy but arousable , normal speech.

- Spinomotor:   No wasting / thinning of muscles. No pain,fatique,fasciculations.
               Right.                  Left
Bulk.      Normal.              Normal
Tone.      Normal.              Normal
Power.   
     UL.     4/5.                          4/5
     LL.      4/5.                         4/5
Reflexes-
     Superficial:         
Corneal :       +.                     +
Conjunctival:   +.                     +
     Deep tendon reflexes
                     Right.                 Left
Biceps.           ++.                      ++
Triceps.          ++.                      ++
Supinator.     ++.                      ++
Knee jerk.     +++.                    +++
Ankle.             ++.                      ++
Plantar.          Flexor.             Flexor.













- Sensory system: no sensory deficit.

- Cranial nerves : 
1: no alternation in smell
2: blurring of vision present, able to differentiate colour.
3;4;6: no double vision . Able to move eyes in all directions
5: normal chewing of food . Sensation over face present
7: eye closure present
8. Hearing present , no tinnitus .
9,10. No difficulty in speech.
11. Normal neck movements in all directions.
12. Tongue rolling present.

-Cerebellar functions: Normal.

-ANS : Able to feel bladder fullness. Regular bowel movements, giddiness on waking up in the morning present. No sweating and palpitations.

-Meninges : No fever , nausea , vomiting or stiffness of neck.

-Perabdominal examination: 
Shape of abdomen - scaphoid and soft
No tenderness and local rise of temperature
No palpable mass,
Hernial orifices: normal
No free fluid and no bruit
Liver and spleen: not palpable
Bowel sounds: heard and normal.

-Respiratory system examination:
Position of trachea: central
No dyspnoea and wheeze
Bilateral air entry present.
normal vesicular breath sounds heard. 
 No adventitious sounds.

Cardiovascular system examination:
S1 and S2 heard, no murmurs.

Based on above findings , the following investigations were sent.

1) hemogram 
2) liver function test
3) kidney function test
4) complete urine examination
5) CT scan- brain. 
6) ECG
7) thyroid function test.
8) fundoscopy
9) serum magnesium
10) Random blood sugar 
11) EEG
            
         Fundoscopy : normal
       
         EEG : normal













PROVISIONAL DIAGNOSIS:
Recurrent epilepsy -? focal seizures progressed to GTCS.  
K/C/O epilepsy-non compliant to medication.


MANAGEMENT:
1) Inj. Levipil 2gm in 100ml NS / IV / stat.
2) Inj. Lorazepam 2cc/ IV/ stat , as seizures repeated 
4) Half hourly bp monitoring and head end elevation.
5) Inj. Eptoin 800mg in 100ml NS / IV/ stat over 30 mins. Followed by Inj EPTOIN 400 mg in 100 ml NS /IV / stat over 20 mins 
6) Inj. MgSO4 1amp in 500ml NS / IV over 2 hrs
7) Inj. Optineuron 1 amp in 100ml NS/ IV OD.
8) Inj. pcm 500mg im sos.
9) Inj. Pan 40mg IV OD.
10)  Inj. Zofer 4mg IV TID.
11)  IVF DNS @ 75ml per hour.

EEG done showing no abnormality